Efecto inhibitorio de fracciones peptídicas obtenidas por ultrafiltración de hidrolizados proteínicos de frijol caupí (Vigna unguiculata), sobre la renina
Resumen
El sistema renina-angiotensina-aldosterona (SRAA) es clave en la fisiopatología de la hipertensión arterial. La renina regula la cascada del SRAA al convertir el angiotensinógeno en angiotensina I, que es una molécula relativamente inactiva. En la presente investigación, se realizó la evaluación in vitro de la actividad inhibitoria de la renina de fracciones peptídicas obtenidas mediante hidrólisis enzimática de la proteína de Vigna unguiculata. La proteína de frijol caupí se hidrolizó con cada uno de dos sistemas enzimáticos, pepsina-pancreatina o Flavourzyme®. La ultrafiltración de los hidrolizados produjo fracciones de diferentes pesos moleculares. La fracción >5 kDa del hidrolizado con Flavourzyme® tuvo la mayor actividad inhibidora de renina con 50,52 % mientras que para el hidrolizado de pepsina-pancreatina, la fracción >10 kDa fue la mejor con 33,46 % de inhibición de renina. Las fracciones peptídicas de los hidrolizados de proteínas de Vigna unguiculata exhibieron actividad antihipertensiva y tienen potencial aplicación como ingredientes en alimentos funcionales.
Citas
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